Table 5.
Treatment characteristics of chronic haemodialysis patients at time of cinacalcet initiation
| No hypocalcemia within 12 months after cinacalcet initiation N = 295 | Hypocalcemia within 12 months after cinacalcet initiation | |||
|---|---|---|---|---|
| Ca at time of cinacalcet initiation | ||||
| Overall Ca ≥ 2.1 mmol/L N = 610 | Low normal Ca 2.10– < 2.50 mmol/L N = 546 | Moderate to high normal Ca ≥ 2.5 mmol/L N = 64 | ||
| Cinacalcet | ||||
| Average daily dose [mg/day], median (Q1, Q3) | 30.0 (12.9, 30.0) | 30.0 (17.1, 30.0) | 30.0 (17.1, 30.0) | 30.0 (30.0, 30.0) |
| Calcitriol/alfacalcidol | ||||
| Use, n (%) | 60 (20) | 130 (21) | 116 (21) | 14 (22) |
| Daily dose [µg/day], median (Q1, Q3) | 0.4 (0.2, 0.5) | 0.3 (0.2, 0.4) | 0.3 (0.2, 0.4) | 0.3 (0.2, 0.6) |
| New users, n (%) | 2 (3) | 4 (3) | 4 (3) | 0 (0) |
| Continuing users, n (%) | 58 (97) | 126 (97) | 112 (97) | 14 (100) |
| Stable dose, n (%) | 47 (81) | 106 (84) | 95 (85) | 11 (79) |
| Up-titration, n (%) | 7 (12) | 9 (7) | 9 (8) | 0 (0) |
| Down-titration, n (%) | 4 (7) | 11 (9) | 8 (7) | 3 (21) |
| Paricalcitol | ||||
| Use, n (%) | 113 (38) | 234 (38) | 207 (38) | 27 (42) |
| Daily dose [µg/day], median (Q1, Q3) | 0.9 (0.6, 1.4) | 0.9 (0.6, 1.2) | 0.9 (0.6, 1.1) | 0.9 (0.7, 1.9) |
| New users, n (%) | 2 (2) | 17 (7) | 17 (8) | 0 (0) |
| Continuing users, n (%) | 111 (98) | 217 (93) | 190 (92) | 27 (100) |
| Stable dose, n (%) | 78 (70) | 164 (76) | 146 (77) | 18 (67) |
| Up-titration, n (%) | 23 (21) | 26 (12) | 21 (11) | 5 (19) |
| Down-titration, n (%) | 10 (9) | 27 (12) | 23 (12) | 4 (15) |
| Calcium-based phosphate binder | ||||
| Use, n (%) | 64 (22) | 140 (23) | 132 (24) | 8 (13) |
| Daily dose [mg/day], median (Q1, Q3) | 1943 (715, 2820) | 1980 (1143, 3150) | 1980 (1143, 3000) | 2133 (1240, 4600) |
| New users, n (%) | 1 (2) | 6 (4) | 6 (5) | 0 (0) |
| Continuing users, n (%) | 63 (98) | 134 (96) | 126 (95) | 8 (100) |
| Stable dose, n (%) | 56 (89) | 120 (90) | 113 (90) | 7 (88) |
| Up-titration, n (%) | 4 (6) | 8 (6) | 8 (6) | 0 (0) |
| Down-titration, n (%) | 3 (5) | 6 (4) | 5 (4) | 1 (13) |
| Dialysate calcium [mmol/L] | ||||
| Missing | 11 (4) | 18 (3) | 14 (3) | 4 (6) |
| ≤ 1.00 | 1 (0) | 2 (0) | 2 (0) | 0 (0) |
| > 1.00– < 1.25 | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| ≥ 1.25– < 1.50 | 146 (49) | 306 (50) | 271 (50) | 35 (55) |
| ≥ 1.50 | 137 (46) | 284 (47) | 259 (47) | 25 (39) |
| Stable concentration, n (%) | 264 (93) | 552 (94) | 497 (94) | 55 (92) |
| Up-titration, n (%) | 8 (3) | 13 (2) | 13 (2) | 0 (0) |
| Down-titration, n (%) | 12 (4) | 24 (4) | 19 (4) | 5 (8) |