Table 6.

Management of hypocalcemia within 90 days following first hypocalcemia episode

Management of hypocalcemia following first hypocalcemic event	Overall			First hypocalcemia
				Mild Ca 2.0– < 2.1 mmol/L N = 415			Moderate Ca 1.87– < 2.0 mmol/L N = 141			Severe Ca < 1.87 mmol/L N = 54
	No. at risk	n	%	No. at risk	n	%	No. at risk	n	%	No. at risk	n	%
Dialysate calcium concentration
Increased	610	102	17	415	60	15	141	30	21	54	12	22
Stable	610	472	77	415	329	79	141	103	73	54	40	74
Decreased	610	15	3	415	13	3	141	2	1	54	0	0
Cinacalcet
Increased	610	91	15	415	67	16	141	21	15	54	3	6
Stable	610	374	61	415	255	61	141	86	61	54	33	61
Discontinued	610	42	7	415	33	8	141	4	3	54	5	9
Reduced	610	102	17	415	59	14	141	30	21	54	13	24
Calcitriol/alfacalcidol
Initiated	486	41	8	326	20	6	115	13	11	45	8	18
Up-titrated	124	30	24	89	23	26	26	5	19	9	2	22
Initiated or up-titrated	610	71	12	415	43	10	141	18	13	54	10	19
Stable	124	73	59	89	53	60	26	14	54	9	6	67
Down-titrated	124	17	14	89	11	12	26	5	19	9	1	11
Discontinued	124	4	3	89	2	2	26	2	8	9	0	0
Paricalcitol
Initiated	394	65	17	258	39	15	96	18	19	40	8	20
Up-titrated	216	54	25	157	40	26	45	11	24	14	3	21
Initiated or up-titrated	610	119	20	415	79	19	141	29	21	54	11	20
Stable	216	115	53	157	84	54	45	22	49	14	9	64
Down-titrated	216	34	16	157	24	15	45	8	18	14	2	14
Discontinued	216	13	6	157	9	6	45	4	9	14	0	0
Calcium-based phosphate binder
Initiated	459	51	11	311	30	10	107	17	16	41	4	10
Up-titrated	151	25	17	104	14	14	34	9	27	13	2	15
Initiated or up-titrated	610	76	13	415	44	11	141	26	18	54	6	11
Stable	151	106	70	104	78	75	34	18	53	13	10	77
Down-titrated	151	14	9	104	8	8	34	5	15	13	1	8
Discontinued	151	6	4	104	4	4	34	2	6	13	0	0
Any expected responses1
No treatment intervention	610	255	42	415	188	45	141	51	36	54	16	30
Any treatment intervention	610	355	58	415	227	55	141	90	64	54	38	70
Any responses2
No treatment intervention	610	175	29	415	130	31	141	33	23	54	12	22
Any treatment intervention	610	435	71	415	285	69	141	108	77	54	42	78

¹Any expected treatment response = for Cinacalcet, discontinued or reduced; for Dialysate Calcium: increased calcium; for other drugs: initiated or up-titrated

²Any treatment = any of the changes listed in table