Table 3.
Comparison of unstimulated analyte expression fluorescence values between diagnostic groups.
| Cytokine | Clinically diagnosed TB (n = 60) vs. Bacteriologically confirmed TB (n = 44) |
OD (n = 327) vs. Bacteriologically confirmed TB (n = 44) |
||
|---|---|---|---|---|
| Estimated difference$ (95% CI) | P# | Estimated difference$ (95% CI) | P# | |
| IL-1b | 0•02 (−0•89, 0•93) | 0•99 | −0•92 (−1•66, −0•19) | 0•002 |
| IL-1ra | 0•05 (−0•86, 0•95) | 0•99 | −1•26 (−2•00, −0•52) | <0•001 |
| IL-2 | 0•07 (−0•84, 0•98) | 0•99 | −0•41 (−1•15, 0•33) | 0•98 |
| IL-4 | 0•21 (−0•70, 1•12) | 0•99 | −0•31 (−1•05, 0•43) | 0•99 |
| IL-5 | 0•12 (−0•79, 1•03) | 0•99 | −0•18 (−0•92, 0•55) | 0•99 |
| IL-6 | −0•05 (−0•86, 0•96) | 0•99 | −1•40 (−2•14, −0•67) | <0•001 |
| IL-7 | 0•16 (−1•07, 0•75) | 0•99 | −0•42 (−1•15, 0•32) | 0•97 |
| IL-8 | 0•20 (−1•11, 0•71) | 0•99 | −1•21 (−1•95, −0•48) | <0•001 |
| IL-9 | −0•18 (−1•09, 0•73) | 0•99 | −0•01 (−0•75, 0•72) | 0•99 |
| IL-10 | 0•33 (−1•24, 0•58) | 0•99 | −0•09 (−0•82, 0•65) | 0•99 |
| IL-12P70 | 0•11 (−0•80, 1•02) | 0•99 | −0•25 (−0•99, 0•49) | 0•99 |
| IL-13 | 0•08 (−0•83, 0•99) | 0•99 | −0•17 (−0•91, 0•56) | 0•99 |
| IL-15 | 0•11 (−0•80, 1•02) | 0•99 | −0•51 (−1•24, 0•23) | 0•71 |
| IL-17 | 0•28 (−0•63, 1•19) | 0•99 | −0•15 (−0•89, 0•58) | 0•99 |
| EOTAXIN | 0•09 (−0•82, 1•00) | 0•99 | −0•36 (−1•10, 0•38) | 0•99 |
| FGFBasic | 0•07 (−0•84, 0•98) | 0•99 | −0•29 (−1•03, 0•44) | 0•99 |
| GCSF | 0•29 (−0•62, 1•20) | 0•99 | −0•34 (−1•07, 0•40) | 0•99 |
| GMCS-F | 0•06 (−0•85, 0•97) | 0•99 | −0•01 (−0•74, 0•73) | 0•99 |
| IFN-γ | −0•02 (−0•93, 0•89) | 0•99 | −0•58 (−1•31, 0•16) | 0•41 |
| IP-10 | 0•07 (−0•84, 0•99) | 0•99 | −0•97 (−1•70, −0•23) | <0•001 |
| MCP-1 | 0•10 (−0•81, 1•01) | 0•99 | −0•80 (−1•53, −0•06) | 0•02 |
| MIP-1a | 0•04 (−0•87, 0•95) | 0•99 | −1•24 (−1•98, −0•50) | <0•001 |
| MIP-1b | −0•11 (−1•02, 0•80) | 0•99 | −0•43 (−1•16, 0•31) | 0•96 |
| PDGFBB | 0•31 (−0•60, 1•22) | 0•99 | −0•20 (−0•94, 0•53) | 0•99 |
| RANTES | −0•02 (−0•93, 0•89) | 0•99 | 0•002 (−0•74, 0•74) | 0•99 |
| TNFa | 0•18 (−0•73, 1•09) | 0•99 | −0•40 (−1•14, 0•33) | 0•98 |
| VEGF | 0•14 (−0•77, 1•05) | 0•99 | −0•29 (−1•03, 0•45) | 0•99 |
$
Estimated difference of log-2 transformed responses;.
#
All 95% confidence intervals (CI) and p-values are adjusted using Sidak correction for the Type I error because of multiple testing; OD = other respiratory diseases but not TB.