Table 4.
Comparison of EC-stimulated analyte expression fluorescence values between diagnostic groups.
| Cytokine | Clinically diagnosed TB (n = 60) vs. Bacteriologically confirmed TB (n = 44) |
OD (n==327) vs. Bacteriologically confirmed TB (n = 44) |
||
|---|---|---|---|---|
| Estimated difference$ (95% CI) | P# | Estimated difference$ (95% CI) | P# | |
| IL-1b | −0•40 (−1•33, 0•52) | 0•99 | −0•29 (−1•04, 0•46) | 0•99 |
| IL-1ra | −0•17 (−1•09, 0•76) | 0•99 | −0•69 (−1•44, 0•06) | 0•12 |
| IL-2 | −0•17 (−1•10, 0•75) | 0•99 | −1•53 (−2•29, −0•78) | <0•001 |
| IL-4 | −0•10 (−1•03, 0•82) | 0•99 | −0•36 (−1•11, 0•39) | 0•99 |
| IL-5 | 0•19 (−0•73, 1•12) | 0•99 | −0•38 (−1•13, 0•37) | 0•99 |
| IL-6 | −0•25 (−1•18, 0•68) | 0•99 | −0•20 (−0•95, 0•55) | 0•99 |
| IL-7 | −0•04 (−0•96, 0•89) | 0•99 | −0•28 (−1•03, 0•47) | 0•99 |
| IL-8 | −0•16 (−1•09, 0•77) | 0•99 | −0•15 (−0•91, 0•60) | 0•99 |
| IL-9 | 0•02 (−0•91, 0•95) | 0•99 | −0•08 (−0•83, 0•67) | 0•99 |
| IL-10 | −0•35 (−1•28, 0•57) | 0•99 | 0•05 (−0•70, 0•80) | 0•99 |
| IL-12P70 | 0•06 (−0•86, 0•99) | 0•99 | −0•43 (−1•18, 0•32) | 0•96 |
| IL-13 | 0•05 (−0•88, 0•98) | 0•99 | −1•57 (−2•33, −0•82) | <0•001 |
| IL-15 | −0•10 (−1•03, 0•82) | 0•99 | −0•45 (−1•20, 0•30) | 0•93 |
| IL-17 | 0•02 (−0•90, 0•95) | 0•99 | −0•33 (−1•08, 0•42) | 0•99 |
| EOTAXIN | 0•03 (−0•92, 0•93) | 0•99 | −0•30 (−1•05, 0•45) | 0•99 |
| FGFBasic | −0•07 (−1•00, 0•85) | 0•99 | −0•43 (−1•18, 0•32) | 0•97 |
| GCSF | −0•27 (−1.20, 0•66) | 0•99 | −0•27 (−1.02, 0•48) | 0•99 |
| GMCS-F | 0•16 (−0•77, 1•08) | 0•99 | −0•74 (−1•49, 0•01) | 0•06 |
| IFN-γ | −0•22 (−1•15, 0•71) | 0•99 | −0•93 (−1•68, −0•18) | 0•002 |
| IP-10 | −0•10 (−1•02, 0•83) | 0•99 | −0•36 (−1•11, 0•39) | 0•99 |
| MCP-1 | −0•23 (−1•15, 0•70) | 0•99 | −0•05 (−0•80, 0•70) | 0•99 |
| MIP-1a | −0•23 (−1•16, 0•70) | 0•99 | −0•10 (−0•85, 0•65) | 0•99 |
| MIP-1b | −0•07 (−1•00, 0•86) | 0•99 | −0•02 (−0•77, 0•73) | 0•99 |
| PDGFBB | 0•25 (−0•68, 1•18) | 0•99 | −0•33 (−1•10, 0•41) | 0•99 |
| RANTES | −0•01 (−0•93, 0•92) | 0•99 | 0•02 (−0•73, 0•77) | 0•99 |
| TNFa | −0•37 (−1•29, 0•56) | 0•99 | −0•45 (−1•20, 0•30) | 0•92 |
| VEGF | −0•32 (−1•25, 0•61) | 0•99 | −0•27 (−1•02, 0•48) | 0•99 |
$
Estimated difference of log-2 transformed responses;.
#
All 95% confidence intervals (CI) and p-values are adjusted using Sidak correction for the Type I error because of multiple testing; OD = other respiratory diseases but not TB.