Table 1.
Summary of the CRISPR-Induced Mutant Rabbit Lines in This Study
Method | System | Rabbits Lines | Gene | Positive Mutation Rabbits | Rabbit with Large Fragment Mutation (% Positive Rabbits) | Rabbits without Large Fragment Mutation (% Positive Rabbits) |
---|---|---|---|---|---|---|
Cas9 | SpCas9 | F1 (Figure S1) | F8 | 7 | 7 (100) | 0 |
F2 (Figure S2) | F9 | 6 | 2 (33.3) | 4 (67.7) | ||
S1 (Figure S3) | Sost | 5 | 3 (80.0) | 2 (20.0) | ||
F3 (Figure S4) | Fbn1 | 7 | 6 (85.7) | 1 (14.3) | ||
G1 (Figure S5) | Ggta | 7 | 2 (28.6) | 5 (71.4) | ||
S2 (Figure S6) | Sry | 5 | 4 (80.0) | 1 (20.0) | ||
xCas9 | T1 (Figure S7) | Tyr | 4 | 2 (50.0) | 2 (50.0) | |
T2 (Figure S8) | Tyr | 7 | 4 (57.1) | 3 (42.9) | ||
BEs | BE4 | D1 (Figure S9) | Dmd | 7 | 0 | 7 (100) |
M1 (Figure S10) | Mstn | 7 | 0 | 7 (100) | ||
T3 (Figure S11) | Tia1 | 7 | 0 | 7 (100) | ||
T4 (Figure S12) | Tyr | 7 | 0 | 7 (100) | ||
ABE | D2 (Figure S13) | Dmd | 7 | 0 | 7 (100) | |
S3 (Figure S14) | Sod1 | 7 | 0 | 7 (100) | ||
xCas9-BE4 | T5 (Figure S15) | Tyr | 7 | 0 | 7 (100) | |
xCas9-ABE | T6 (Figure S16) | Tyr | 7 | 0 | 7 (100) |