Fig. 1.

ctDNA landscape in metastatic breast cancer (N: 255). Shown is a heatmap of detected genomic alterations across the entire cohort. The y-axis includes alterations in descending frequency with the most common alterations detected at the following frequencies: TP53 (189), PIK3CA (144), ERBB2 (77), ESR1 (75), MYC (57), EGFR (55), FGFR1 (49), CCNE1 (42), NF1 (38), and ARID1A (35). The following variants were included on the x-axis from left to right: amplifications (ampl), copy number variants (CNV), fusions (fus), deletions (del), insertions (ins), frameshift (fs), splicing variants (Spl), premature termination codons (PTC), and single nucleotide variants (SNV). Boxplots including the interquartile range and outliers for allele frequency are included. Each row represents a gene. A heatmap scale is included in the lower right corner.