Figure 5.

miR-873-5p Was Responsible for YY1-Mediated Regulation on the Tumor Formation Ability In Vivo

(A and B) Images of tumors size and number when nude mice were injected with different numbers of MCF-7 cells (PLVX, PLVX-YY1, miR-873-5p mimics, PLVX-YY1 plus miR-873-5p mimics), respectively (A) and the tumor-formation rate was examined (B). (C) The stem cell frequency in theses groups depicted in (A) was calculated using the ELDA analysis. (D and E) Images of tumors size and number when nude mice were injected with different numbers of MDA-MB-231 cells (shNC, shYY1, miR-873-5p inhibitor, shYY1 plus miR-873-5p inhibitor) (D), and the tumor-formation rate was measured (E). (F) The stem cell frequency in theses groups depicted in (D) was calculated using the ELDA analysis.The data are presented as the mean ± SD, n ≥ 3, ∗p < 0.05, ∗∗p < 0.01, versus control group.