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Three models of memory T cell formation. (A) Memory T cells differentiate from naïve T cells in a stepwise manner as they progress from Tscmto Tcm, and then Tem, a more terminally differentiated phenotype. (B) Memory T cells are from discrete subsets that contain memory precursor genes in the naïve T cell population. (C) Memory T cells are derived from surviving effector T cells as the methylation patterns in memory T cells are similar to those in effector T cells
