Table 1.
Summary of GSH associated miRNAs in cancer.
Name | Associated cancer type | Target | Influence to GSH | Model of evidence | Reference |
---|---|---|---|---|---|
miR-27a | Bladder cancer, colorectal cancer | SLC7A11, ZBTB10 | Up/Down | Cell culture, animal models | 42,43 |
miR-143 | Colorectal cancer | GPX | Up | Animal models | 199 |
miR-17 | Prostate cancer | GPX2 | Up | Cell culture, animal models | 56 |
miR-17-3p | Prostate cancer | GPX2 | Up | Cell culture, animal models | 57 |
miR-196a | Lung cancer | GPX3 | Up | Cell culture, animal models | 58 |
miR-921 | Lung cancer | GPX3 | Up | Cell culture | 59 |
miR-124 | Colorectal cancer | GST | Up | Cell culture, animal models | 48 |
Let-7a-5p | Prostate cancer | GST | Up | Cell culture, animal models | 49 |
miR-92b-3p | Prostate cancer | GST | Up | Cell culture, animal models | 49 |
miR-129-5P | Colorectal cancer cells | GST | Up | Cell culture | 50 |
miR-144 | Prostate cancer | GST | Up | Cell culture, animal models | 51 |
miR-153-1/2 | Prostate cancer | GST | Up | Cell culture, animal models | 51 |
miR-302c-5p | Colorectal cancer | GST | Up | Cell culture | 50 |
miR-3664-5p | Colorectal cancer | GST | Up | Cell culture | 50 |
miR-3714 | Colorectal cancer | GST | Up | Cell culture | 50 |
miR-513a-3p | Colorectal cancer, lung cancer | GST | Up | Cell culture | 200 |
miR-590-3p/5p | Prostate cancer | GST | Up | Cell culture, animal models | 51 |
miR-133a/b | Bladder cancer, lung cancer, prostate cancer, colorectal cancer, ovarian cancer, head and neck squamous cell carcinoma | GST | Up | Cell culture, animal models | 52,53,201 |
miR-130b | Ovarian cancer | GST | Up | Cell culture | 202 |
miR-186 | Ovarian cancer | GST | Up | Cell culture | 203 |
miR-34b | Prostate cancer | MYC | Up | Cell culture | 204 |
miR-K12-11 | Kaposi’s sarcoma | xCT | Up | Cell culture | 205 |
miR-18a | Hepatocellular carcinoma | GCL | Down | Cell culture, animal models | 37 |
miR-218 | Bladder cancer | GCL | Down | Cell culture | 38 |
miR-21 | Lung cancer | GSH | Down | Cell culture | 44 |
miR-24-2 | Colorectal cancer | GSH | Down | Clinical samples | 45 |
miR-497 | Cervical cancer | GSH | Down | Cell culture | 46 |
miR-503 | Hepatocellular carcinoma | GSH | Down | Cell culture | 47 |
miR-152 | Hepatocellular carcinoma | GST | Down | Cell culture | 39 |
miR-155 | Lung cancer | GST | Down | Cell culture | 40 |
miR-326 | Glioma | PKM2 | Down | Cell culture | 41 |
miR-125b | Chronic lymphocytic leukemias | GSH | Unknown | Cell culture | 206 |