Table 3.

Summary of NRF2 associated miRNAs in cancer.

Name	Associated cancer type	Target	Influence to NRF2	Model of evidence	Reference
miR-141	Hepatocellular carcinoma, ovarian cancer	KEAP1	Up	Cell culture	88,91–93
miR-23a	Leukemic	KEAP1	Up	Cell culture, animal models	94
miR-432	Esophageal cancer	KEAP1	Up	Cell culture	92,95
miR-7	Neuroblastoma cells	KEAP1	Up	Cell culture	92
miR-200a	Breast cancer, esophageal cancer, hepatocellular carcinoma, and pancreatic adenocarcinomas	KEAP1,	Up	Cell culture, animal models	81,92,96,97,215,216
miR-155	Lung cancer	NRF2	Up	Cell culture	217
miR-101	Hepatocellular carcinoma, prostate cancer	NRF2, SOD1	Up/Down	Cell culture, animal models	88,105,218
miR-1	Lung cancer, prostate cancer	NRF2, SOD1	Up/Inhibited by NRF2	Cell culture, animal models	105,107
miR-206	Lung cancer, prostate cancer	NRF2, SOD1	Up/Inhibited by NRF2	Cell culture, animal models	105–107
miR-148b	Endometrial cancer	ERMP1	Down	Cell culture	219
miR-129	Esophageal cancer	NRF2	Down	Cell culture, animal models	80
miR-129-5a	Esophageal cancer	NRF2	Down	Cell culture, animal models	80,81
miR-129-5p	Esophageal cancer	NRF2	Down	Cell culture, animal models	80
miR-142	Esophageal cancer	NRF2	Down	Cell culture	82
miR-144	Hepatocellular carcinoma, leukemia, hepatocellular carcinoma, neuroblastoma	NRF2	Down	Cell culture	88,89
miR-144-3p	Melanoma, lung cancer, and acute myeloid leukemia	NRF2	Down	Cell culture	86,87,220,221
miR-153	Neuroblastoma, breast cancer, and oral squamous cell carcinoma	NRF2	Down	Cell culture	82,90
miR-200c	Lung cancer	NRF2	Down	Cell culture, animal models	222
miR-212-3p	Melanoma	NRF2	Down	Cell culture	86
miR-23b-3p	Melanoma	NRF2	Down	Cell culture	86
miR-27	Neuroblastoma	NRF2	Down	Cell culture, animal models	223
miR-28	Breast cancer, esophageal cancer	NRF2	Down	Cell culture	81,224
miR-340	Hepatocellular carcinoma, esophageal cancer	NRF2	Down	Cell culture	85,88,92
miR-34a	Breast cancer, colon cancer, ovarian cancer, and lung cancer	NRF2	Down	Cell culture	225,226
miR-450	Esophageal cancer	NRF2	Down	Cell culture	83
miR-450a	Esophageal cancer	NRF2	Down	Cell culture, animal models	80,81
miR-495	Nonsmall-cell lung cancer	NRF2	Down	Cell culture	227
miR-507	Esophageal cancer	NRF2	Down	Cell culture, animal models	80,81,84
miR-634	Esophageal cancer	NRF2	Down	Cell culture, animal models	80,81,85
miR-93	Pancreatic adenocarcinomas, breast cancer	NRF2	Down	Cell culture, animal models	97,221
miR-93-5p	Melanoma	NRF2	Down	Clinical samples	86
miR-125b	Acute myelocytic leukemia, oral squamous cell carcinoma, and renal cancer	NRF2	Down/Induced by NRF2	Cell culture, animal models	98,99,228
miR-181c	Colorectal cancer	–	Inhibited by NRF2	Cell culture, animal models	102
miR-378	Mucoepidermoid carcinoma	–	Inhibited by NRF2	Cell culture, animal models	103
miR-122	Hepatocellular carcinoma	–	Inhibited by NRF2	Cell culture	104
miR-17-5p	Multiple myeloma	–	Inhibited by NRF2	Cell culture, animal models	66
miR-29B1	Acute myelocytic leukemia	–	Induced by NRF2	Cell culture	98
miR-129-3p	Hepatocellular carcinoma	–	Induced by NRF2	Cell culture, animal models	100
miR-380-3p	Neuroblastoma	–	Induced by NRF2	Cell culture, animal models	101