Table 4.

Summary of ROS associated miRNAs in cancer.

Name	Associated cancer type	Target	Influence to ROS	Model of evidence	Reference
miR-124	Non-small cell lung cancer	TXNRD1	Up	Cell culture	120
miR-125a	Osteosarcoma	Estrogen-related receptor alpha	Up	Cell culture	229
miR-128a	Medulloblastoma	BMI-1	Up	Cell culture	230
miR-139-5p	Breast cancer	Unknown	Up	Cell culture, animal models	231
miR-143	Colorectal cancer	SOD1	Up	Cell culture	121
miR-146a	Lung cancer, ovarian Cancer	Catalase, SOD2	Up	Cell culture, animal models	117,118
miR-146b-5p	Leukemic	Unknown	Up	Cell culture	232
miR-15	Colorectal cancer, cancer stem cells	C-MYC	Up	Cell culture, animal models	233
miR-155	Glioma, pancreatic cancer	MAPK13, MAPK14, and Foxo3a	Up	Cell culture, animal models	234,235
miR-15a-3p	Lung cancer	P53	Up	Cell culture	236
miR-16	Colorectal cancer, cancer stem cells	C-MYC	Up	Cell culture, animal models	233
miR-186	Colorectal cancer	CKII	Up	Cell culture	237
miR-193a-3p	Glioma	γH2AX	Up	Cell culture	238
miR-210	Cancer stem cells, glioma	P53	Up	Cell culture, animal models	239
miR-212	Colorectal cancer	MnSOD	Up	Clinical samples	240
miR-216b	Colorectal cancer	CKII	Up	Cell culture	237
miR-22	Hepatocellular carcinoma	SIRT-1	Up	Cell culture	241
miR-223	Breast cancer	HAX-1	Up	Cell culture	242
miR-23b-3p	Acute myeloid leukemia	PrxIII	Up	Cell culture	243
miR-25-5p	Colorectal cancer	SOX10	Up	Cell culture	244
miR-26a-5p	Acute myeloid leukemia	PrxIII	Up	Cell culture	243
miR-26b	Small cell lung cancer	Myeloid cell leukemia 1 protein	Up	Cell culture, animal models	245
miR-30	Gastric cancer	P53	Up	Cell culture	246
miR-337-3p	Colorectal cancer	CKII	Up	Cell culture	237
miR-34c	Nonsmall cell lung cancer	HMGB1	Up	Cell culture	247
miR-371-3p	Lung cancer	PRDX6	Up	Cell culture, animal models	248
miR-422a	Gastric cancer	PDK2	Up	Cell culture, animal models	249
miR-4485	Breast cancer	Mitochondrial protein	Up	Cell culture, animal models	133
miR-4673	Lung cancer	8-Oxoguanine-DNA Glycosylase-1	Up	Cell culture	250
miR-504	Lung cancer	P53	Up	Cell culture	251
miR-506	Lung cancer	P53, NF-κB	Up	Cell culture, animal models	252
miR-509	Breast cancer	P53	Up	Cell culture	253
miR-526b	Breast cancer	Thioredoxin Reductase 1	Up	Cell culture	119
miR-551b	Lung cancer	MUC1	Up	Cell culture	254
miR-655	Breast cancer	Thioredoxin Reductase 1	Up	Cell culture	119
miR-661	Colorectal cancer	Hexose-6-phosphate dehydrogenase, pyruvate kinase M2	Up	Cell culture	255
miR-760	Colorectal cancer	CKII	Up	Cell culture	237
miR-92	Hepatocellular carcinoma	Unknown	Up	Clinical samples	256
miR-128	Glioma, hepatocellular carcinoma	PKM2	Up/Down	Cell culture	257
miR-145	Colorectal cancer, hepatocellular carcinoma	SOD1, PKM2	Up/Down	Cell culture	121,258
miR-211	Myeloma, oral carcinoma	PRKAA1, TCF12	Up/Down	Cell culture, animal models	259,260
miR-222	Hepatocellular carcinoma, breast cancer	NF-κB, TGF-β	Up/Down	Cell culture, animal models	261,262
miR-23a/b	Myeloma, renal cancer	C-MYC, POX	Up/Down	Cell culture, animal models	263,264
miR-29	Ovarian cancer, lung cancer, and lymphoma	C-MYC, SIRT1	Up/Down	Cell culture, animal models	265,266
miR-34a	Gastric cancer, glioma	NOX2	Up/Down	Cell culture	267
Let-7	Hepatocellular carcinoma, prostate cancer, and pancreatic cancer	Heme oxygenase-1, P53	Up/Down	Cell culture, animal models	123,268
miR-33a	Glioma, hepatocellular carcinoma	SIRT6	Up/Down	Cell culture, animal models	269
miR-221	Hepatocellular carcinoma, breast cancer	NF-κB, TGF-β, and DICER	Up/Down/Induced by ROS	Cell culture, animal models	261,262,270
miR-21	Lung cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, ovarian cancer, and prostate cancer	SOD, MAPK, SOD2, Glucose, NFκB, STAT3, POX, and PDCD4	Up/Down/Induced by ROS	Cell culture, animal models	108,112,114,271
miR-17-92	Gastric cancer, lung cancer	C-MYC, P53, and NFκB	Up/Down/Inhibited by ROS	Cell culture	137,272,273
miR-181	Hepatocellular carcinoma, uterine leiomyoma	Unknown	Up/Induced by ROS	Cell culture	132,274
miR-200	Breast cancer, cancer stem cells, hepatocellular carcinoma, and lung cancer	P53, PRDX2, GAPB/NRF2, SESN1	Up/Induced by ROS	Cell culture, animal models	222,275–277
miR-34	Cancer stem cells, bladder cancer, lung cancer	C-MYC, P53	Up/Induced by ROS	Cell culture	278,279
miR-182	Uterine leiomyoma, lung cancer	PDK4	Up/Induced by ROS	Cell culture, animal models	132,133
miR-199	Gastric cancer, ovarian cancer	DNMT1	Up/Inhibited by ROS	Cell culture	134
miR-20a	Breast cancer, pancreatic cancer	BECN1, ATG16L1, and SQSTM1	Up/Inhibited by ROS	Cell culture, animal models	136,280
miR-125b	Hepatocellular carcinoma, ovarian cancer, and breast cancer	Hexokinase 2, DNMT1, and HAX-1	Up/Inhibited by ROS	Cell culture, animal models	228,281
miR-1246	Breast cancer	NF-κB, TGF-β	Down	Cell culture	124
miR-137	Ovarian cancer	C-MYC	Down	Cell culture, animal models	125
miR-193b	Liposarcoma	Antioxidant methionine sulfoxide reductase A	Down	Cell culture, animal models	127
miR-199a-3p	Testicular cancer	Transcription factor specificity protein 1	Down	Cell culture	126
miR-26a	Hepatocellular carcinoma	Triglyceride, totalcholesterol, malondialdehyde	Down	Cell culture	128
miR-30c-2-3p	Breast cancer	NF-κB, TGF-β	Down	Cell culture	282
miR-346	Ovarian cancer	GSK3B	Down	Cell culture	283
miR-373	Breast cancer	NF-κB, TGF-β	Down	Cell culture, animal models	123
miR-520	Breast cancer	NF-κB, TGF-β	Down	Cell culture, animal models	123
miR-7	Nonsmall cell lung cancer	MAFG	Down	Cell culture	284
miR-885-5p	Hepatocellular carcinoma	TIGAR	Down	Cell culture	285
miR-99a	Lung cancer	NOX4	Down	Cell culture, animal models	122
miR-133a	Rhabdomyosarcoma	9	Induced by ROS	Cell culture, animal models	129
miR-150-3p	Hepatocellular carcinoma	–	Induced by ROS	Cell culture	130
miR-1915-3p	Hepatocellular Carcinoma	–	Induced by ROS	Cell culture	130
miR-206	Rhabdomyosarcoma	–	Induced by ROS	Cell culture, animal models	131
miR-34a-3p	Hepatocellular carcinoma	–	Induced by ROS	Cell culture, animal models	129
miR-34a-5p	Hepatocellular carcinoma	–	Induced by ROS	Cell culture	130
miR-638	Hepatocellular carcinoma	–	Induced by ROS	Cell culture	130
miR-125	Gastric cancer	–	Inhibited by ROS	Cell culture	134
miR-145-5p	Gastric cancer	–	Inhibited by ROS	Cell culture, animal models	135
miR-17-5p	Pancreatic cancer	–	Inhibited by ROS	Cell culture, animal models	136
miR-27a	Pancreatic cancer, colorectal cancer	–	Inhibited by ROS	Cell culture, animal models	286
miR-328	Gastric cancer	–	Inhibited by ROS	Cell culture, animal models	287
miR-329	Breast cancer	–	Inhibited by ROS	Cell culture, animal models	288
miR-362-3p	Breast cancer	–	Inhibited by ROS	Cell culture, animal models	288