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. 2020 Jul 24;11:3730. doi: 10.1038/s41467-020-17489-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — EBOV GP-specific CD4⁺ T cell (left panel) and CD8⁺ T cell (right panel) responses of EBOV_S (n = 27) after 9 days of EBOV GP-specific (EBOV1 and EBOV2 peptide pools) T cell expansion in vitro (all cytokines) (a). Analysis of the co-expression of CD107a and IFN-γ by EBOV GP-specific CD8 T cells from EBOV_S (n = 27) after 9 days of antigen-specific T cell expansion in vitro (b). Median values ± IQR are shown, and Friedman’s test was used for comparisons. Functional composition of EBOV GP-specific CD4⁺ and CD8⁺ T cell responses (c). Responses are color coded according to the combinations of cytokines produced. The arcs identify cytokine-producing subsets (IFN-γ, IL-2, MIP-1β, and TNF) within the CD4⁺ and CD8⁺ T cell populations. Source data are provided as a Source Data file.