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. 2020 Jul 24;10:12393. doi: 10.1038/s41598-020-69339-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Experimental timeline. A2A-Cre mice were injected with AAV-eYFP or AAV-mCherry to label D2-MSNs prior to chronic social defeat stress (CSDS). (b) Social interaction behavior after 10 days CSDS or in unstressed controls. Data points represent individual mice. (c) Representative image of sparsely labeled MSNs in the NAc and schematic for dendritic spine analysis workflow. Secondary dendrites of single D2-MSNs are imaged at 63x, then analyzed in Neuron Studio. Identified spines are confirmed in 3D reconstructed segments.