Table 2.
Oligonucleotide sequences used for DNMT1 structural analyses.
| Sequence | Rank in NNCGNN profile | PDB number | Reference |
|---|---|---|---|
| TTCCGTAA | 2 | 6W8W | This study |
| TTACGGAA | 32 | 6W8V | This study |
| AGGCGGCC | 177 | 4DA4 | Ref. 17 |
| TCGCGAGA | 254 | – | This study |
Substrate preferences of DNMT1 determined in the deep enzymology experiments are indicated by the rank of the substrate in the NNCGNN profile, where 1 represents the highest preference and 256 the lowest. The central CpG site is printed in bold letters and the N2 flanks are underlined.