Table 1.
Haemodynamic profile of cardiogenic shock (baseline 2) induced by ethanol.
| Baseline 1 | Baseline 2 | p value | |
|---|---|---|---|
| Heart rate, bpm | 85 ± 4 | 78 ± 3 | 0.04 |
| Systolic arterial pressure, mmHg | 98 ± 3 | 69 ± 2 | < 0.01 |
| Mean arterial pressure, mmHg | 79 ± 13 | 53 ± 11 | < 0.01 |
| Diastolic arterial pressure, mmHg | 68 ± 14 | 44 ± 12 | < 0.01 |
| LVESP, mmHg | 96 ± 3 | 70 ± 3 | < 0.01 |
| LVEDP, mmHg | 8 ± 1 | 11 ± 1 | < 0.01 |
| LV dP/dtmax, mmHg s−1 (n = 11) | 1,755 ± 66 | 1,272 ± 77 | < 0.01 |
| LV dP/dtmin, mmHg s−1 (n = 11) | − 1,858 ± 124 | − 833 ± 65 | < 0.01 |
| Right atrial pressure, mmHg | 9 ± 1 | 12 ± 1 | 0.01 |
| Mean pulmonary arterial pressure, mmHg | 19 ± 1 | 21 ± 1 | 0.14 |
| Cardiac index, L min−1.m−2 | 1.8 ± 0.1 | 1.2 ± 0.1 | < 0.01 |
| Stroke volume index, mL m−2 | 21 ± 1 | 15 ± 1 | < 0.01 |
| LV SW, mmHg mL (n = 6) | 2,587 ± 282 | 791 ± 132 | < 0.01 |
| ESPVR, mmHg mL−1 (n = 5) | 1.27 ± 0.06 | 0.62 ± 0.13 | 0.02 |
| Fractional area change, % (n = 9) | 49 ± 7 | 35 ± 5 | < 0.01 |
| Carotid blood flow, mL min−1 (n = 13) | 404 ± 31 | 294 ± 21 | < 0.01 |
| SvO2, % | 82 ± 1 | 73 ± 2 | < 0.01 |
Data from n = 17 independent experiments (if not otherwise mentioned), expressed as mean ± SE. p value refers to comparison between baseline 1 and 2 by using a paired student’s t-test.
LVESP left ventricular end-systolic pressure, LVEDP left ventricular end-diastolic pressure, dP/dt first derivative of left ventricular pressure; LVSW Left ventricular stroke work; ESPVR end-systolic pressure volume relationship, SvO2 mixed venous saturation of oxygen.