Table 2.
Haemodynamic parameters during three consecutive hours from baseline 2 (cardiogenic shock).
| Baseline 2 | H + 60 | H + 120 min | H + 180 min | Intragroup comparison (time effect) | Intergroup comparison (group effect) | |
|---|---|---|---|---|---|---|
| HR, bpm | ||||||
| SHAM | 82 ± 5 | 81 ± 5 | 83 ± 5 | 82 ± 4 | 0.99 | 0.02 |
| SHOCK | 78 ± 3 | 75 ± 4 | 73 ± 5 | 69 ± 4 | 0.44 | |
| CVP, mmHg | ||||||
| SHAM | 9 ± 1 | 9 ± 1 | 11 ± 1 | 11 ± 1 | 0.31 | < 0.01 |
| SHOCK | 12 ± 1 | 12 ± 1 | 13 ± 1 | 13 ± 1 | 0.46 | |
| MPAP, mmHg | ||||||
| SHAM | 20 ± 1 | 22 ± 1 | 22 ± 2 | 23 ± 1 | 0.43 | 0.59 |
| SHOCK | 21 ± 1 | 20 ± 1 | 21 ± 1 | 22 ± 1 | 0.39 | |
| LVESP, mmHg | ||||||
| SHAM | 91 ± 3 | 89 ± 3 | 93 ± 4 | 90 ± 4 | 0.78 | < 0.01 |
| SHOCK | 70 ± 3 | 64 ± 2 | 63 ± 3 | 62 ± 2 | 0.13 | |
| LVEDP, mmHg | ||||||
| SHAM | 10 ± 6 | 11 ± 6 | 12 ± 4 | 12 ± 4 | 0.84 | 0.21 |
| SHOCK | 11 ± 1 | 12 ± 1 | 14 ± 2 | 14 ± 2 | 0.48 | |
| MAP, mmHg | ||||||
| SHAM | 75 ± 5 | 72 ± 3 | 77 ± 3 | 73 ± 3 | 0.80 | < 0.01 |
| SHOCK | 53 ± 3 | 48 ± 2 | 47 ± 2 | 45 ± 2* | 0.04 | |
| dP/dtmax, mmHg s−1 | ||||||
| SHAM | 1,851 ± 143 | 1,799 ± 146 | 1,966 ± 188 | 1,858 ± 246 | 0.93 | < 0.01 |
| SHOCK (n = 11) | 1,272 ± 77 | 1,144 ± 57 | 1,127 ± 64 | 1,079 ± 98 | 0.52 | |
| dP/dtmin, mmHg s−1 | ||||||
| SHAM | − 1,860 ± 277 | 1,653 ± 155 | − 1,770 ± 153 | − 1,613 ± 157 | 0.80 | < 0.01 |
| SHOCK (n = 11) | − 833 ± 65 | − 785 ± 44 | − 736 ± 52 | − 674 ± 74 | 0.58 | |
| CI, L min−1 | ||||||
| SHAM | 1.7 ± 0.1 | 1.7 ± 0.1 | 1.7 ± 0.1 | 1.7 ± 0.1 | 0.95 | < 0.01 |
| SHOCK | 1.2 ± 0.1 | 1.2 ± 0.1 | 1.1 ± 0.1 | 1.0 ± 0.1 | 0.55 | |
| SVI, mL m−2 | ||||||
| SHAM | 22 ± 2 | 22 ± 1 | 22 ± 1 | 22 ± 1 | 0.99 | < 0.01 |
| SHOCK (n = 15) | 15 ± 1 | 14 ± 1 | 14 ± 1 | 15 ± 1 | 0.53 | |
| SvO2, % | ||||||
| SHAM | 83 ± 2 | 82 ± 3 | 82 ± 2 | 82 ± 2 | 0.99 | < 0.01 |
| SHOCK (n = 15) | 73 ± 2 | 72 ± 12 | 67 ± 2 | 64 ± 2* | 0.03 | |
| CBF, mL min−1 | ||||||
| SHAM | 419 ± 42 | 394 ± 40 | 380 ± 43 | 366 ± 47 | 0.84 | < 0.01 |
| SHOCK (n = 13) | 293 ± 21 | 277 ± 15 | 269 ± 21 | 261 ± 25 | 0.69 | |
Data from n = 8 SHAM and n = 17 SHOCK independent experiments (if not otherwise mentioned), expressed as mean ± SE. Two-way ANOVA was performed for comparison of multiple means. * p<0.05 versus baseline 2.
HR heart rate, CVP central venous pressure, MPAP mean pulmonary arterial pressure, LVESP left ventricular end systolic pressure, LVEDP left ventricular end diastolic pressure, MAP mean arterial pressure, dP/dt first derivative of left ventricular pressure, CI cardiac index, SVI stroke volume index, SvO2 mixed venous oxygen saturation, CBF carotid blood flow.