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. 2020 Jul 24;11:3717. doi: 10.1038/s41467-020-17495-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The surface of the nsp10-nsp16 was colored according to the electrostatic surface potential. Sinefungin is localized in the SAM binding pocket. The RNA binding pocket is characterized by a positively charged surface that interacts with the RNA phosphate backbone. The RNA cap is located at the top of the RNA binding pocket while the active site is located at the interface of the RNA and SAM binding pockets. The RNA was modeled in the RNA binding pocket based on a structural alignment of SARS-CoV-2 MTase with Dengue MTase (PDB code 5dto) and manually adjusted in Coot.