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. 2020 Jul 24;11(7):573. doi: 10.1038/s41419-020-02749-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Wound-healing assays showed the effects of VEGFR2 expression on the anti-migration ability of anlotinib. Representative images of migration are shown in the left panel. Degrees to which wounds healed in the indicated groups are shown in the histogram. Significantly decreased inhibition effects on migration of anlotinib were observed when VEGFR2 was silenced in HCCC9810 and REB ICC cells lines; b transwell assays revealed the effects of VEGFR2 expression on the anti-invasion ability of anlotinib. Inhibition effects of anlotinib were significantly reduced when VEGFR2 expression was knocked down. The histogram shows the relative proportions of invading cells; c CCK8 experiments were performed to confirm the effects of VEGFR2 in anlotinib-induced inhibition of proliferation. When VEGFR2 expression was knocked down, anlotinib’s antiproliferative ability was significantly reduced. Representative images were photographed using an inverted microscope and are shown in the left panel. The histogram shows the OD values for each group after 48 h of drug treatment. *P < 0.05; **P < 0.01; ***P < 0.001. Scale bars = 100 μm.