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. 2020 Jul 24;10:12392. doi: 10.1038/s41598-020-69122-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative images from TPLSM of collateral blood flow after dMCAO. (a,b) Representative images of a control rat (a) and RIPerC-treated rat (b). Panels of TPLSM images on the right show maximum intensity projections from region demarcated with rectangular box in LSCI images. Scale bar, 1 mm. (c,d) Magnified images showing vessels demarcated by the yellow boxes for the control rat shown in (a). Yellow arrows denote vessel diameter 60 min after dMCAO, and are superimposed on the same vessel and region 150 and 270 min after dMCAO. Clear constriction of vessel lumen diameter is apparent in control rats. (e,f) Magnified images of vessels demarcated by the orange boxes in the RIPerC treated rat in (b). Again, orange arrows show vessel diameter at 60 min after dMCAO and are repeated in images acquired 150 and 270 min after ischemic onset. With RIPerC, vessel diameter is maintained throughout the imaging period.