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. 2020 Jul 24;10:12392. doi: 10.1038/s41598-020-69122-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of RIPerC on relative flux and infarct volume in aged rats after dMCAO. (a) Relative flux for arteriole segments within or downstream of ACA–MCA collateral anastomoses in RIPerC treated and control rats are shown. Relative flux shows overall flow through these segments during and after RIPerC (or sham treatment), accounting for diameter and velocity measurements, relative to flux prior to treatment. Individual means for each animal are plotted, and red lines show the group mean. RIPerC exhibited a strong statistical trend towards a persistent improvement in flux, with flux relative to pre-treatment values approximately 163% and 178% greater during and after treatment, respectively, in RIPerC treated rats relative to controls. The volume of early ischemic damage from TTC staining for RIPerC and control rats is shown in (b) and (c). A significant reduction in early infarct was observed in RIPerC treated aged rats.