Skip to main content
. 2020 Jun 26;41:101045. doi: 10.1016/j.molmet.2020.101045

Figure 6.

Figure 6

SIK1 overexpression inhibited gluconeogenesis and increased PDE4 activity in primary mouse hepatocytes. Primary mouse hepatocytes were overexpressed with SIK1 via transient plasmid transfections for 24 h and then the mRNA expression of SIKs (A) and Western blotting analysis of SIK1 (B) were conducted, and the PDE4 activity (C), cAMP levels (D), mRNA expression of gluconeogenic genes (E), and gluconeogenesis (F) were examined. All of the results are presented as the mean ± SEM (n = 5). ∗P < 0.05 and ∗∗P < 0.01 vs the vector control group.