Table 2.
Enrichment analyses of transcriptomic data
| Pathways Upregulated in BM-MSC | Ref. No. | Pathways Upregulated in lr-MSC | Ref. No. |
|---|---|---|---|
| Response to lipopolysaccharide | 144 | Cell adhesion | 144 |
| Response to drug | 144 | Integrin-mediated signaling pathways | 144 |
| Cell-to-cell adhesion | 144 | Positive regulation of epithelial cell proliferation | 144 |
| Response to hypoxia | 144 | Extracellular matrix organization | 144 |
| Aging | 144 | Cell migration and morphogenesis | 55, 144 |
| Embryonic development | 55, 121, 125, 144, 148 | Negative regulation of ossification | 144 |
| Signal transduction | 144 | Embryonic organ system morphogenesis | 55, 121, 125, 144, 148 |
| Response to activity | 144 | Signal transduction: small GTPase mediated | 55, 144 |
| Negative regulation of apoptotic process | 144 | Cellular response to growth factor stimulus | 144 |
| Response to organic cyclic compound | 144 | Collagen biosynthetic process | 144 |
| Positive regulation of angiogenesis, blood vessel development | 55, 144 | Positive regulation of transcription from RNA | 55, 144 |
| Response to γ-irradiation | 144 | Activation of MAPK activity | 144 |
| Inflammatory response | 55, 121, 125, 144, 148 | Heart development | 144 |
| Negative regulation of cell development | 55, 121, 125, 144, 148 | Positive regulation of cell proliferation | 144 |
| Proximal distal pattern formation | 55, 121, 125, 144, 148 | Negative regulation of mitotic division | 55, 121, 125, 144, 148 |
| Skeletal system development | 55, 121, 125, 144, 148 | Meiotic nuclear division | 55, 121, 125, 144, 148 |
| Negative regulation of multicellular organismal process | 55, 121, 125, 144, 148 | Chromosome segregation | 55, 121, 125, 144, 148 |
| Cell division | 55, 121, 125, 144, 148 | ||
| Digestive tract development | 55, 121, 125, 144, 148 | ||
| Mitotic cell cycle process | 55, 121, 125, 144, 148 |
Table comprises significantly different gene ontologies (GO) between lung-resident mesenchymal stromal cells (lr-MSC) and bone marrow-derived mesenchymal stromal cells (BM-MSC), downregulated in lr-MSC compared with BM-MSC (left column) and upregulated in lr-MSC compared with BM-MSC (right column), determined by enrichment analyses on genes. If analyses were not already provided, we conducted our own analyses of the differentially expressed genes, with P ≤ 0.05 from expression results and a false discovery rate P ≤ 0.05 using Panther (http://pantherdb.org). Analyses conducted by us are italicized and bolded where there is overlap between our analyses and those published previously (55, 121, 125, 144, 148).