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. 2020 Jul 9;10(18):8264–8280. doi: 10.7150/thno.45537

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Left panel: comparative total cellular uptake and internalization kinetics for [¹⁷⁷Lu]DOTA-r-a-ABA-iodoCPCR4 and [¹⁷⁷Lu]PentixaTher. Right panel: comparative externalization kinetics for [¹⁷⁷Lu]DOTA-r-a-ABA-iodoCPCR4 and [¹⁷⁷Lu]PentixaTher (after a 120 min pre-incubation to allow tracer uptake) under conditions allowing (medium only) or inhibiting (10 μM AMD3100in external medium) tracer reinternalization (recycling). Experiments were performed at 37°C using Chem-1 cells stably transfected with hCXCR4. Each experiment was performed in triplicate, and results are means ± SD.