Table 3.
Lipophilicity (log PO/W) of the reference ligands [68Ga]PentixaFor and [177Lu]PentixaTher and of selected 68Ga/177Lu-labeled ligands with modified linker structure. Data are means ± SD (n=6).
| Peptide | log PO/PBS |
|---|---|
| [68Ga]PentixaFor | -2.9 ± 0.08 |
| [177Lu]PentixaTher | -1.8 ± 0.20 |
| [68Ga]DOTA-r-G-ABA-iodoCPCR4 | -3.0 ± 0.02 |
| [177Lu]DOTA-r-G-ABA-iodoCPCR4 | -2.7 ± 0.05 |
| [68Ga]DOTA-r-a-ABA-CPCR4 | -3.6 ± 0.06 |
| [177Lu]DOTA-r-a-ABA-CPCR4 | -3.0 ± 0.13 |
| [68Ga]DOTA-r-a-ABA-iodoCPCR4 | -3.3 ± 0.02 |
| [177Lu]DOTA-r-a-ABA-iodoCPCR4 | -2.8 ± 0.04 |