Table 4.
Tumor/organ ratios for [177Lu]PentixaTher, [177Lu]DOTA-r-a-ABA-CPCR4 and [177Lu]DOTA-r-a-ABA-iodoCPCR4 in Daudi xenograft bearing CB-17 SCID mice at 48h p.i. (groups of n=4-5 animals). Data are means ± SD.
[177Lu]PentixaTher | [177Lu]DOTA-r-a-ABA-CPCR4 | [177Lu]DOTA-r-a-ABA-iodoCPCR4 | |
---|---|---|---|
t/blood | 201 ± 27 | 949 ± 146 | 320 ± 104 |
t/heart | 31 ± 4 | 111 ± 20 | 42 ± 7 |
t/lung | 16 ± 5 | 47 ± 22 | 14 ± 2 |
t/liver | 0.4 ± 0.1 | 1.0 ± 0.2 | 0.6 ± 0.1 |
t/spleen | 2.1 ± 0.5 | 8.3 ± 2.8 | 3.0 ± 0.7 |
t/stomach | 27 ± 6 | 46 ± 32 | 58 ± 12 |
t/small intestine | 29 ± 6 | 55 ± 36 | 50 ± 20 |
t/colon | 13 ± 5 | 20 ± 10 | 19 ± 13 |
t/kidney | 2.7 ± 0.4 | 2.9 ± 0.4 | 3.1 ± 0.9 |
t/muscle | 85 ± 15 | 413 ± 100 | 226 ± 36 |