Figure 6.

BAT-Exos preferentially accumulate in liver and promote oxygen consumption in hepatocytes. A. Representative images of in vivo distribution of DiR-labeled exosome by in vivo imaging system. Exosomes were labeled with fluorescent dye DiR and injected into mice via intravenous injection. B. Quantification of fluorescence intensity of different organs. C. Confocal microscopy of liver section. Colocalization of DiI-labeled exosomes with E-cadherin. Scale bar=25 µm. D. Cell oxygen consumption rate (OCR) of AML12 cells with indicated treatment measured by seahorse cell metabolism analyzer. eWAT, epididymal white adipose tissue; iWAT, inguinal white adipose tissue.