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. 2020 Jul 9;10(18):8211–8226. doi: 10.7150/thno.44419

Figure 5.

Figure 5

Hypoxic exosomal circ-133 promotes tumor metastasis through targeting of GEF-H1/RhoA. (A) High intension imaging cell analysis revealed that hypoxic derived exosomes enriched circ-133 increase CRC cells migration, (n=3). (B) Quantitative analysis of A, (n=3). (C) Validation of hypoxic exosomes derived circ-133 enhance the migration ability of CRC cells by transwell assays, (n=3). (D) Quantitative analysis of C, (n=3). (E) Wound healing assay demonstrated that hypoxic exosomes promote CRC cell migration, (n=3). (F) Immunofluorescence assay was used to detect E-cadherin membrane distribution in each treatment group, (n=3).