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. 2020 Jul 9;10(18):8211–8226. doi: 10.7150/thno.44419

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In vivo verification for hypoxic exosomes derived circ-133 promotes cancer metastasis. (A (a)) A flow chart depicting the in vivo experimental design. (A (b)) The morphology of the tumor tissues excised from tumor-implanted mice (n = 6). (B) Weight changes during tumor-bearing period in each group (n=6). (C and D) Quantitative analysis of xenografted tumor volume and Weight (n=6). (E) During the tumor-bearing period, survival of mice in each group. (F) The level of circ-133 in exosomes that isolated from plasma of tumor-implanted mice (n=6). (G) qRT-PCR analysis of circ-133 and GEF-H1 mRNA in implanted tumors (n=6). (H) Relative numbers of CTCs in each group (n=6). (I) WB analysis of E-cadherin, GEF-H1 and RhoA in implanted tumors (n=6). (J) Immunohistochemically analysis of the paraffin-embedded tumor tissues using E-cadherin and GEF-H1 antibody, respectively (n=6).