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Schematic representation of the NONO-STAT3 gene regulation mechanism NONO regulates STAT3 expression via its direct interactions with STAT3 RNA and protein. NONO directly binds to the STAT3 RNA region and recruits the STAT3 protein to STAT3 target promoters, such as the CCND1 promoter. NONO also modulates STAT3 transcriptional activity. Finally, NONO modulates STAT3 stability and thereby contributes to cancer cell proliferation and chemoresistance in TNBC.
