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. 2020 Jul 17;12:5957–5974. doi: 10.2147/CMAR.S258196

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© 2020 Tian et al.

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Interaction between tumor cells and immune cells by immune checkpoints. T cells and NK cells express various immune checkpoints, which can bind to ligands on tumor cells, T_reg cells and Kupffer cells and be inhibited (CD96 binds to CD111 and CD115; TIGHT binds to CD115 and CD112; NKG2A binds to HLA-E; PD-1 binds to PD-L1; and CTLA-4 binds to CD80 and CD86).

Abbreviations: PD-1, programmed death-1; CTLA-4, cytolytic T lymphocyte-associated antigen-4; NKG2A, natural killer cell group 2A; TIGIT, T-cell immunoglobulin and ITIM domain; HLA-E, human leukocyte antigen-E.