FIGURE 2.

Whole‐genome sequencing of hESC and differentiated RPE cells. A, Flowchart describing HS980 (p22), hESC‐RPE, and HS980 (p38) whole‐genome DNA sequence analysis pipelines for various germline and somatic variant calling, filtration, and annotation. B, Upper panel: Genome‐wide functional annotation of germline and somatic SNVs based on their relative location in the genome. Lower panel: Bar chart showing different annotation for germline and somatic Exonic SNVs. hESC, human embryonic stem cell; RPE, retinal pigment epithelial; SNV, single nucleotide variant