Table 1.
Hub Genes in the Module Related with Metastasis Risk
| Probes | Co-Expression Analysis | DEG Analysis* | Hub Gene in PPI Network | ||||
|---|---|---|---|---|---|---|---|
| GS | p.GS | GM | p.GM | logFC | adj.P.Val | ||
| AHSP | −0.42932 | 0.014204 | 0.968948 | 9.28E-20 | −0.04145 | 0.948473 | YES |
| BCO2 | 0.362559 | 0.041418 | −0.97809 | 5.27E-22 | −0.15161 | 0.853744 | NO |
| C5orf15 | 0.378244 | 0.032797 | −0.40986 | 0.019824 | 0.540303 | 0.089561 | NO |
| CA1 | −0.40648 | 0.020967 | 0.965192 | 5.02E-19 | 0.190827 | 0.778192 | NO |
| CADM3 | −0.40105 | 0.022914 | 0.535513 | 0.001586 | 0.272196 | 0.498392 | NO |
| DEFA1 | −0.56734 | 0.000709 | 0.949456 | 1.21E-16 | −0.34926 | 0.610902 | NO |
| DEFA1B | −0.47512 | 0.005997 | 0.978491 | 4.01E-22 | −0.04359 | 0.948756 | YES |
| DEFA3 | −0.5108 | 0.002814 | 0.963389 | 1.06E-18 | −0.14401 | 0.842645 | YES |
| FCN1 | −0.37647 | 0.033692 | 0.721898 | 3.11E-06 | −0.39204 | 0.615102 | NO |
| FGFBP2 | −0.38578 | 0.029205 | 0.66501 | 3.30E-05 | 0.24652 | 0.381499 | NO |
| FLJ20489 | −0.38563 | 0.029275 | 0.809693 | 2.00E-08 | −0.67961 | 0.028783 | NO |
| GCGR | 0.389613 | 0.027509 | −0.96634 | 3.05E-19 | −2.431 | 0.003958 | NO |
| HBD | −0.43655 | 0.012489 | 0.973409 | 9.33E-21 | −0.23322 | 0.801679 | YES |
| HMOX1 | −0.48127 | 0.005293 | 0.592417 | 0.000354 | 1.241792 | 0.061738 | NO |
| HS3ST2 | −0.4478 | 0.010168 | 0.800832 | 3.71E-08 | 0.322107 | 0.649323 | NO |
| IL8RB | −0.47365 | 0.006176 | 0.929002 | 1.73E-14 | −0.01471 | 0.968263 | NO |
| LILRA5 | −0.37948 | 0.032182 | 0.827859 | 5.05E-09 | 0.071237 | 0.863889 | NO |
| LOC653600 | −0.4404 | 0.011649 | 0.938467 | 2.16E-15 | −0.00815 | 0.981527 | NO |
| LTF | −0.43388 | 0.013103 | 0.959807 | 4.19E-18 | −1.21129 | 0.027201 | YES |
| MCOLN1 | −0.4066 | 0.020924 | 0.810286 | 1.91E-08 | 0.166043 | 0.669995 | NO |
| MS4A6E | −0.35669 | 0.04508 | 0.956674 | 1.26E-17 | 0.125213 | 0.69205 | NO |
| RAB5C | −0.35346 | 0.047198 | 0.661589 | 3.74E-05 | −0.29436 | 0.201098 | NO |
| S100A12 | −0.44648 | 0.01042 | 0.709792 | 5.38E-06 | −0.19093 | 0.487956 | YES |
| SERPINB2 | −0.38296 | 0.030513 | 0.96272 | 1.38E-18 | 0.05374 | 0.888049 | NO |
| SLC40A1 | −0.40331 | 0.022085 | 0.614439 | 0.000183 | 0.396953 | 0.453982 | NO |
| SLC4A1 | −0.38809 | 0.028174 | 0.922576 | 6.08E-14 | −1.31157 | 0.008869 | NO |
| SPTA1 | −0.38479 | 0.029662 | 0.926101 | 3.09E-14 | 0.038285 | 0.919528 | NO |
Note: *Differentially expressed genes between 35 ccRCC tissues and 9 normal kidney tissues in GSE105288.
Abbreviations: GM, cor.gene module membership; GS, cor.gene trait significance.