Table 2.
Univariate and Multivariate Cox Regression Analyses of Prognostic Factors in the Jiaxing Set
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (years) | 1.02 (0.98–1.04) | 0.20 | ||
| Sex (male vs female) | 0.89 (0.55–1.47) | 0.70 | ||
| Site (Head vs body and tail) | 0.84 (0.48–1.46) | 0.50 | ||
| Tumor size (cm) | 1.23 (1.05–1.44) | 0.02 | 1.20 (0.97–1.48) | 0.095 |
| Vascular infiltration (Absent vs present) | 1.70 (0.98–2.97) | 0.07 | ||
| Nerve infiltration (Absent vs present) | 1.32 (0.74–2.37) | 0.30 | ||
| Grade (Well vs poor) | 2.14 (2.19–3.54) | 0.003 | 2.43 (1.43–4.15) | 0.001* |
| T stage (T1+T2 vs T3+T4) | 1.86 (1.13–3.06) | 0.02 | 1.58 (0.81–3.05) | 0.177 |
| LNM (Absent vs present) | 1.82 (1.10–3.02) | 0.02 | 2.37 (1.31–4.31) | 0.005* |
| AJCC stage (I+II vs III+IV) | 2.15 (1.25–3.67) | 0.009 | 1.49 (0.80–2.62) | 0.220 |
| DHRS9 (Low vs high) | 3.15 (1.54–6.45) | <0.001 | 2.27 (1.08–4.77) | 0.031* |
Note: *P < 0.05.
Abbreviations: AJCC, The American Joint Committee on Cancer; CI, confidence interval; DHRS9, dehydrogenase/reductase member 9; HR, hazard ratio; LNM, lymph node metastasis; HR, hazard ratio; T stage, “tumor” attributes in 8th edition TNM classification.