Table 3.
Univariate and Multivariate Cox Regression Analyses of Prognostic Factors in the TCGA Set
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (years) | 1.03 (1.01–1.05) | 0.007 | 1.02 (1–1.05) | 0.017* |
| Sex (male vs female) | 1.21 0.81–1.83) | 0.40 | ||
| Site (Head vs body and tail) | 0.52 (0.29–0.97) | 0.03 | 0.63 (0.34–1.18) | 0.153 |
| Tumor size (cm) | 1.01 (0.90–1.13) | 0.90 | ||
| Grade (Well vs poor) | 2.18 (1.15–4.13) | 0.009 | 1.63 (0.86–3.13) | 0.137 |
| T stage (T1+T2 vs T3+T4) | 1.11 (0.72–1.70) | 0.60 | ||
| LNM (Absent vs present) | 2.22 (1.34–3.68) | 0.001 | 1.79 (1.06–3.01) | 0.030* |
| AJCC stage (I+II vs III+IV) | 1.53 (1.01–2.33) | 0.05 | ||
| DHRS9 (Low vs high) | 2.04 (1.34–3.10) | < 0.001 | 1.75 (1.14–2.68) | 0.010* |
Note: *P < 0.05.
Abbreviations: AJCC, The American Joint Committee on Cancer; CI, confidence interval; DHRS9, dehydrogenase/reductase member 9; HR, hazard ratio; LNM, lymph node metastasis; TCGA, The Cancer Genome Atlas; HR, hazard ratio; T stage, “tumor” attributes in 8th edition TNM classification.