Table 2.
Compounds that Appear as Hits in Multiple Studies
Drug | Touret et al.3 IC50 (μM) | Heiser et al.5 IC50 (μM) | Riva et al.6 IC50 (μM) | Ellinger et al.4 IC50 (μM) | Jeon et al.2 IC50 (μM) | Mirabelli et al.1 IC50 (μM) | Overlap |
---|---|---|---|---|---|---|---|
Remdesivir | 1.65 | x | 0.62 | 0.76 | 11.41 | 0.10 | 6 |
Clofazimine | x | x | 0.08 | 3 | |||
Acitretin | x | x | 2 | ||||
Almitrine | x | 1.42 | 2 | ||||
Gilteritinib | 6.76 | 0.22 | 2 | ||||
Hexachlorophene | x | 0.90 | 2 | ||||
Lopinavir | 19.11 | 9.12 | 2 | ||||
Mefloquine | 14.15 | 4.33 | 2 | ||||
Niclosamide | 0.28 | 0.14 | 2 | ||||
Tetrandrine | 1.1 | 3 | 2 | ||||
Tioguanine | 1.71 | 0.022 | 2 |
If available, the IC50 value calculated in each study is shown. Otherwise, the hit is marked by an “x.” Note that different studies use different assays and cell lines to measure dose response.