Table 2.
Detection of SARS-CoV-2 antigens in the placental tissue of COVID-19 positive mothers.
| Study | N | COVID-19 | GA | Histological findings Histological findings | SARS-CoV-2 detection method and findings | |
|---|---|---|---|---|---|---|
| 1 | Patane et al. [3] | 22 | 2 | 37w6da 35w1da |
Chronic intervillosits with macrophages |
Single-molecule RNA in situ hybridization SARS-CoV-2 spike antigen in villous syncytiotrophoblasts |
| 2 | Algarroba et al. [10] | 1 | 0 | 28w4d | Focal villous edema Decidual vasculopathy |
Transmission electron microscopy Virions were visible in syncytiotrophoblasts and villi |
| 3 | Penfield et al. [11] | 11 | 0 | 26w–41w | NA |
PCR Three of 11 COVID-19 positive placental swabs were positive |
N, total number of placentas; GA, weeks of gestation; COVID-19, number of COVID-19-positive neonates.
a
GA indicates the gestational weeks for COVID-19-positive neonates only.