Table 1.
Characteristics of the study population and risk factors for lymphoid malignancies.
| Characteristics | Total number of HIV-infected people, n (column%) N=531 460 |
Number with first primary lymphoid malignancies, n (row %) N=6513 |
aHR (95% CI)a |
|---|---|---|---|
| Age at the start of follow-up (years)b | |||
| <30 | 108 564 (20.4) | 916 (0.8) | … |
| 30–39 | 169 265 (31.9) | 2299 (1.4) | … |
| 40–49 | 166 995 (31.4) | 2236 (1.3) | … |
| 50–59 | 67 797 (12.8) | 820 (1.2) | … |
| ≥60 | 18 839 (3.5) | 242 (3.7) | … |
| Sex/risk group | |||
| MSM | 186 606 (35.1) | 2481 (1.3) | Ref |
| Male IDU | 64 351 (12.1) | 839 (1.3) | 0.7 (0.7–0.8) |
| MSM/ IDU | 21 956 (4.1) | 323 (1.5) | 0.9 (0.8–1.1) |
| Male other/unknown | 112 168 (21.1) | 1432 (1.3) | 0.8 (0.8–0.9) |
| Female IDU | 32 230 (6.1) | 321 (1.0) | 0.6 (0.5–0.7) |
| Female other/unknown | 114 149 (21.5) | 1117 (1.0) | 0.8 (0.7–0.8) |
| Race/ethnicity | |||
| Non-Hispanic white | 123 091 (23.2) | 1751 (1.4) | Ref |
| Non-Hispanic black | 265 576 (50.0) | 2912 (1.1) | 0.9 (0.8–0.9) |
| Hispanic | 133 316 (25.0) | 1761 (1.3) | 1.1 (1.0–1.1) |
| Other/multiple/unknown | 9477 (1.8) | 89 (0.9) | 0.9 (0.7–1.1) |
| Prior AIDS diagnosisc | |||
| No | 203 978 (38.4) | 1408 (0.7) | Ref |
| Yes | 327 482 (61.6) | 5105 (1.6) | 2.4 (2.2–2.5) |
| Calendar year of cohort entry | |||
| 1996–2000 | 98289 (18.5) | 2143 (2.2) | Ref |
| 2001–2003 | 152 668 (28.7) | 2305 (1.5) | 0.8 (0.7–0.8) |
| 2004–2007 | 126 586 (23.8) | 1308 (1.0) | 0.4 (0.3–0.4) |
| 2008–2015 | 153 917 (29.0) | 757 (0.5) | 0.1 (0.1–0.1) |
| Time since HIV diagnosis (years)c | |||
| 0–4.9 | 112 064 (21.1) | 2,310 (2.1) | Ref |
| 5–9.9 | 127 004 (23.9) | 1675 (1.3) | 0.1 (0.1–0.1) |
| >10 | 228 625 (43.0) | 1720 (0.8) | 0.02 (0.02–0.02) |
| Missing | 63 767 (12.0) | 808 (1.3) | 0.04 (0.03–0.04) |
The number of cancers for time-dependent variables (age categories, prior AIDS diagnosis, and time since HIV diagnosis) are shown for when the cancers occurred. Cancer registries included in the study (years of coverage): Colorado (1998–2015), Connecticut (2005–10), Georgia (2004–12), Maryland (2008–12), Michigan (1996–2010), New Jersey (1996–2012), New York (2001–12), North Carolina (1996–2014), Puerto Rico (2003–12), and Texas (1999–2015). aHR, adjusted hazard ratio; CI, confidence intervals; IDU, injection drug users; MSM, men who have sex with men.
Adjusted for sex/risk group, race/ethnicity, calendar year of cohort entry, and prior AIDS diagnosis and time since HIV diagnosis as time-varying covariates.
Age was used as the time scale in Cox regression models, so aHRs are not shown.
Prior AIDS diagnosis and time since HIV diagnosis were used as time-varying covariates.