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. 2020 Jul 25;39:142. doi: 10.1186/s13046-020-01623-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Sirt6 expressions were upregulated and correlated with adverse outcomes in DLBCL. a Sirt6 was upregulated in DLBCL (n = 163) in contrast to normal samples based on the GSE83632 data set. b Kaplan-Meier survival curve analysis indicated that high Sirt6 expression in DLBCL appeared to be correlated with shorter overall survival based on analysis of the GSE32918 data set (n = 249, p = 0.0023). c Compared to samples of RHL, expression levels of Sirt6 were significantly increased in DLBCL tissues. Upper: bar = 50 μm, lower: bar = 100 μm. d Kaplan–Meier survival curve analysis indicated that high Sirt6 expression in DLBCL appeared to be correlated with shorter overall survival based on analysis of our IHC data (n = 60, p = 0.039). e Aberrantly raised Sirt6 mRNA expression levels were observed in DLBCL cell lines (LY1, LY8, Val, LY3) compared to those in control cells (N1, N2, N3). f Western blotting assays showed high expression of Sirt6 protein in DLBCL cells. ***p < 0.001