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. 2020 Jul 25;39:142. doi: 10.1186/s13046-020-01623-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Knockdown of Sirt6 inhibited activation of PI3K/Akt/mTOR signaling pathway. a GSEA according to the RNA-seq implicated that Sirt6 was functionally enriched in the PI3K/Akt signaling pathway and FoxO signaling pathway. b Western blot was conducted to assess the phosphorylated (p) and total (t) protein levels of PI3K signaling cascades. PI3K p110α and its downstream targets, including Akt (Ser473) and mTOR protein, were observed to be dramatically decreased in Sirt6 knockdown cells in comparison to control cells. The tumor suppressor FoxO1 protein increased in shSirt6 cells. c Decreased activation of PI3K signaling was observed in shSirt6-treated mice. d IGF-1-induced DLBCL cell (LY1 and LY8) proliferation is inhibited by Sirt6-depletion. e LY1 cell transfected with shSirt6 or shControl, serum starved for 48 h, and treated with IGF-1. Decreased activation of PI3K signaling was observed in sh-Sirt6-treated cell. f Schematic description of Sirt6 mediated PI3K, FoxO, and DNA damage signaling