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. 2020 Jul 6;117(29):17260–17268. doi: 10.1073/pnas.2002352117

Fig. 6.

Fig. 6.

ECORE optical recording and MEA electric recording of hippocampal brain slices. (A) Bright-field image of a cultured hippocampal brain slice. (B) MEA electric recording shows sporadic spikes of neuronal activities from a brain slice. (C) After a brain slice is exposed to 20 μM of carbachol, MEA recording shows a strong increase in the spiking frequency. (D) ECORE optical recording shows sparse and spontaneous spiking activities from a brain slice. (E) ECORE optical recording shows a drastic increase in spiking frequency after 20 μM of carbachol treatment. (F) ECORE optical recording shows the carbachol-induced high spiking frequency gradually decreases during hypoxia.