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. 2020 Jul 6;117(29):17166–17176. doi: 10.1073/pnas.2002266117

Fig. 3.

Fig. 3.

Global deletion of ERβ exacerbates experimental ileitis in female SAMP mice. SAMP mice lacking global expression of ERβ (SAMPΔERβ mice) were generated by back-crossing SAMP mice with ERβ-KO mice. (A) Representative H&E-stained proximal ileal tissue from 6- and 20-wk-old SAMPΔERβ mice. (Scale bars, 10 μM.) (B) Total inflammatory scores are shown for SAMPΔERβ mice at 6, 10, 15, and 20 wk of age. Data represent the mean ± SEM (**P ≤ 0.01; ***P ≤ 0.001, n = 8 to 14 per group). (C) Relative gene expression of selected proinflammatory genes in full-thickness proximal ileal tissues isolated from 6- or 20-wk old SAMPΔERβ mice is expressed as a heat map. F, female; M, male. *P ≤ 0.05.