Fig. 3.

Interactions of the TLR5 recognition site (C. jejuni residues 88 to 98) with the next 11-start flagellin subunit (S+11). (A) Each subunit in the filament contacts four other subunits. The subunits that contact a single flagellin (S0) are S+5, S+6, S+11, and S+16. (B) Comparison of the contacts between the TLR5 site (pink) and the next 11-start subunit, S+11 (blue), in C. jejuni (Left) and B. subtilis (Right). Residues that are not identical between the two TLR5 sites are shown in gold for C. jejuni and dark grey for B. subtilis. (C) Alignment of the TLR5 sequences from C. jejuni flagellin with those of five flagellins from different species whose high-resolution structures have been determined by cryo-EM.