Fig. 7.

Structural overviews of ARG2 bound to two inhibitory antibodies (Fabs), comparing the parent inhibitory antibody (C0020187) to an affinity-matured therapeutic lead (C0021158). (A) ARG2 trimer (blue cartoon) bound to Fab C0020187 and (C) to Fab C0021158 (PDB ID code 6SS2) (VH/CH in orange and VL/CL in light orange, CDRs in yellow and light yellow for VH and VL, respectively) shown in “top” view. In the active sites, manganese ions are shown as purple spheres. (B and D) A 90° rotated “side” view of A and C.