Fig. 5.

Discovery of thrombin inhibitors from the protease-focused DECL. (A) Analysis of enrichment of building blocks in the selection of thrombin with the library. The resulting enrichment values (AC-zscore-n) (36) were compared by plotting the enrichment in the target sample (x axis) against enrichment in the NTC sample (y axis). The higher the number in the x axis, the stronger the enrichment of synthons. (B) Structure of the top two thrombin hits 5 and 6 identified from the selection experiment. In the library pool, these molecules are attached to the DNA via the linker at the methyl amide site.