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. 2020 Jul 8;117(29):16782–16789. doi: 10.1073/pnas.2005447117

Fig. 6.

Fig. 6.

Synthesis and biological evaluation of thrombin hits. (A) On-DNA resynthesis of two hits to obtain small-molecule DNA-conjugates DNA-5 and DNA-6. (B) Off-DNA resynthesis of the top hit 5. (C) Inhibition of thrombin by DNA-5 and DNA-6 compared with argatroban. (D) Dose–response curves of thrombin inhibition by compound 5 and argatroban. (E) Inhibition constant (apparent Ki) values of synthesized hits. DNA-5 is 10-fold more potent than DNA-6. Compound 5 is 10-fold more potent than argatroban against thrombin.