Figure 2.

(A–R) In the rabbit model, early radiotherapy significantly reduced the number of fibroblasts in hypertrophic scar. (A, B) The non-resection group and the resection and non-radiotherapy group showed a large number of fibroblasts in the hypertrophic scar. (C–F) In the early postoperative radiotherapy groups, fibroblasts were significantly reduced. (G, H) The late postoperative radiotherapy groups showed a large number of fibroblasts. (I) The quantification of fibroblast numerical area density (NA). (J, K) In the non-resection group and the resection and non-radiotherapy group, a large number of dense collagen fibers can be seen. (O–Q) Collagen fibers were denser in the late postoperative radiotherapy groups than in the early postoperative radiotherapy groups, except the 48-hour postoperative radiotherapy group. (R) The quantification of collagen fiber area density (AA). Scale bar=50 μm.