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Genome architecture of SARS-CoV-2. As a positive single-stranded RNA virus, SARS-CoV-2 contains a 5′ capped RNA which has a leader sequence (LS), poly-A tail at the 3′ end, and 5′ and 3′ UTR. It contains the following genes: ORF1a, ORF1b, spike (S), ORF3a, ORF3b, envelope (E), membrane (M), ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF14, nucleocapsid (N), and ORF10
