Fig. 23.

Analysis of intrinsic disorder propensity of Nsp16. Graphs a–c represent the intrinsic disorder profiles of Nsp9 protein of a SARS-CoV-2, b human SARS, and c bat CoV. Colour schemes are similar to those given in Fig. 3. d A 1.95 Å resolution crystal structure (PDB ID: 6W75) of the Nsp10–Nsp16 complex of SARS-CoV-2. Nsp16 of residues 2–298 is represented using pink colour, while Nsp10 of residues 18–139 is shown in cornflower blue colour. e A 2.60 Å crystal structure (PDB ID: 3R24) of human SARS Nsp10–Nsp16 complex. Chain A shown in turquoise colour corresponds to residues 3–294 of Nsp16