Table 3.

Evaluation of the mean predicted percentage disorder in non-structural proteins of novel SARS-CoV-2, human SARS, and bat CoV

Proteins	SARS-CoV-2		Human SARS (UniProt ID: P0C6X7)		Bat CoV (SARS-like) (UniProt ID: P0C6W2)
	Length of protein (residues) (NCBI RefSeq accession ID)	Mean PPID	Length of protein (residues)	Mean PPID	Length of protein (residues)	Mean PPID
Nsp1 (host translation inhibitor)	180 (1–180) (YP_009725297.1)	12.78	180 (1–180)	14.44	179 (1–179)	12.85
Nsp2	638 (181–818) (YP_009725298.1)	5.17	638 (181–818)	2.04	639 (180–818)	2.03
Nsp3 (papain-like proteases)	1945 (819–2763) (YP_009725299.1	7.40	1922 (819–2740)	7.91	1916 (819–2734)	7.78
Nsp4	500 (2764–3263) (YP_009725300.1	0.80	500 (2741–3240)	0.60	500 (2735–3234)	0.60
Nsp5 (3CL-Pro)	306 (3264–3569) (YP_009725301.1	1.96	306 (3241–3546)	1.96	306 (3235–3540)	1.96
Nsp6	290 (3570–3859) (YP_009725302.1	1.03	290 (3547–3836)	1.03	290 (3541–3830)	1.03
Nsp7 (multimeric RNA polymerase)	83 (3860–3942) (YP_009725303.1)	9.64	83 (3837–3919)	9.64	83 (3831–3913)	9.64
Nsp8 (multimeric RNA polymerase)	198 (3943–4140) (YP_009725304.1)	23.74	198 (3920–4117)	23.74	198 (3914–4111)	22.22
Nsp9	113 (4141–4253) (YP_009725305.1)	7.08	113 (4118–4230)	7.96	113 (4112–4224)	7.08
Nsp10	139 (4254–4392) (YP_009725306.1)	5.04	139 (4231–4369)	5.04	139 (4225–4363)	5.04
Nsp12 (RNA-directed RNA polymerase, RDRP)	932 (4393–5324) (YP_009725307.1)	0.43	932 (4370–5301)	0.43	932 (4364–5295)	0.43
Nsp13 (viral helicase)	601 (5325–5925) (YP_009725308.1)	0.67	601 (5302–5902)	0.67	601 (5296–5896)	0.67
Nsp14 (guanine-N7 methyltransferase/ExoN-nsp14)	527 (5926–6452) (YP_009725309.1)	0.38	527 (5903–6429)	0.38	527 (5897–6423)	0.57
Nsp15 (uridylate-specific endoribonuclease/NendoU)	346 (6453–6798) (YP_009725310.1)	1.73	346 (6430–6775)	2.60	346 (6424–6769)	2.60
Nsp16 (2′-O-methyltransferase)	298 (6799–7096) (YP_009725311.1)	5.37	298 (6776–7073)	3.02	298 (6770–7067)	3.02