Table 1. Summary of METTL3 and METTL14 related pathways in urological tumors.

Diseases	Component	Role	Source of experimental evidence	Regulation	Potential signal pathway	Author & Refs
	METTL3	Tumor suppressor	RCC and matched histologically-normal renal tissues are from 145 RCC patients; RCC cell lines (CAKI-1, CAKI-2 and ACHN); a normal renal tubular epithelial cell line (HK-2); BALB/c nude mice	Down-regulation	METTL3-PI3K/AKT/mTOR METTL3-EMT	Li et al. (2017a), Li et al. (2017b)
	METTL3	Tumor suppressor	528 patients with CNV data and pathology reports from the TCGA database; GSEA database	Up-regulation	VHL-HIF-ZNF217-METTL3-PI3K/AKT/mTOR VHL-HIF-ZNF217-METTL3-p53	Zhou et al. (2019)
Kidney cancer	METTL14	Tumor suppressor	528 patients with CNV data and pathology reports from the TCGA database; GSEA database	Up-regulation	VHL-HIF-ZNF217-METTL14- PI3K/AKT/mTOR VHL-HIF-ZNF217-METTL14-p53	Zhou et al. (2019)
	METTL14	Tumor suppressor	Online databases (TCGAportal,GTExPortal, UALCAN,GEPIA2,MEXPRESS, RMBasev2.0,OncoLnc,starBase, circBank,STRING…)	Down-regulation	circRNAs-miRNAs-METTL14-PTEN-AKT/PKB	Wang et al. (2019)
	METTL14	Tumor suppressor	17 groups of renal cell carcinoma tissues and adjacent tissues received in patients with partial or complete kidney resection; Renal cancer cell line (OS-RC-2,786-O,HEK, -293, SN12-PM6, SW839, A498); Human cortical proximal tubule epithelial cell line (HK-2); Nude mice; Online databases (TCGA, UALCAN…)	Down-regulation	METTL14-P2RX6-Ca2+-p-ERK1/2-MMP9	Gong et al. (2019)
	METTL3	Oncogene	Human/mouse bladder cancer samples; bladder cancer cell lines (5637, UM-UC-3); Immortalized epithelial cells (SV-HUC-1); GSEA database	Up-regulation	METTL3-AFF4 /NF- κB/ MYC	Cheng et al. (2019)
	METTL3	Oncogene	Human/mouse bladder cancer samples; bladder cancer cell lines (EJ, T24)	Up-regulation	METTL3-DGCR8-pri-miR221/222-PTEN	Han et al. (2019)
Bladder cancer	METTL3	Oncogene	Formalin-fixed paraffin-embedded (FFPE) tissue from 114 cases of bladder cancer and 30 cases of cystitis with radical cystectomy and bladder biopsy; Human prostate epithelial cell line (RWPE-1); Human bladder cancer cell line (T24, UM-UC-3); urethral epithelial cells (SV-HUC-1); 3-methylcholesterol transformed urethral epithelial cells (MC-SV-HUC T2);NOD/SCID mice	Up-regulation	METTL3 -CDCP1	Yang et al. (2019)
	METTL3	Oncogene	TCGA GDAC Firehose; bladder cancer cell lines(T24)	Up-regulation	METTL3- ITGA6	Jin et al. (2019)
	METTL3	Oncogene	Human bladder cancer samples (T24, UM-UC-3); normal human urothelium cell line SV-HUC-1	Up-regulation	METTL3/YTHDF2-SETD7/KLF4 m6A axis	Xie et al. (2020)
	METTL14	Tumor suppressor	Primary bladder cancer specimens from 6 bladder cancer patients	Down-regulation	METTL14-Notch1	Gu et al. (2019)
Prostate cancer	METTL3	Oncogene	Human prostate cancer cell lines(LNCaP, PC3, C4-2, C4-2B, DU-145); Human normal prostate epithelial cell line(RWPE-1); Six-week-old male NOD/SCID mice	Up-regulation	METTL3-SHH/GLI1-c-Myc/cyclin D1	Cai et al. (2019)
	METTL3	Oncogene	15 localized prostate cancer tissues with bone metastasis and corresponding adjacent tissues; the human prostate cancer cells PC3 and LNCaP; twenty 5-week-old male SCID mice	Up-regulation	METTL3/HuR-ITGB1	Li et al. (2020)
	METTL3	Oncogene	48 prostate cancer tissues and adjacent normal ones (3 cm away from the tumor tissues); human prostate cells RWPE-2; human prostate cancer cells PC3 and LNCaP	Up-regulation	METTL3-LEF1-Wnt/β-catenin	Ma, Cao & Zhao (2020)